Homosalate
product_name Homosalate
CAS_number 118-56-9
formula C16H22O3
molar_mass 262.35 g/mol
pub_chem_CID 23966
drug_bank DB11017
chem_spider 22410
bioavailability Not well characterized
protein_binding High (likely to plasma proteins)
metabolism Primarily hepatic
elimination_halflife Uncertain


FAQ

What is Homosalate and how does it work in sunscreen formulations?
Homosalate is an organic compound predominantly used in sunscreen formulations. It belongs to the salicylate class of chemicals and functions as a UV filter. The primary role of Homosalate is to absorb ultraviolet (UV) radiation from the sun, specifically UVB rays, which are primarily responsible for causing sunburn and contributing to skin cancer. When applied to the skin in the form of a sunscreen, Homosalate absorbs these harmful rays and converts them into less harmful heat, which is then released from the skin. This process helps to protect the skin cells from damage caused by UV exposure.

In the broader spectrum of sunscreen ingredients, Homosalate is valued for its ability to blend well with other chemicals and enhance the overall UV protection of the product. Often, sunscreens combine multiple UV filters to ensure comprehensive protection against both UVA and UVB rays. Homosalate pairs effectively with other UV filters like Avobenzone or Octocrylene, providing a synergistic effect that results in higher SPF formulations. Another advantage of Homosalate is its compatibility with cosmetic formulations, as it does not impart an unpleasant odor or greasy feel, contributing to the overall consumer appeal of the sunscreen products.

Homosalate operates within the permissible concentrations defined by regulatory authorities such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). Typically, it is used in concentrations up to 15% in the U.S. and 10% in Europe. These regulations ensure the ingredient is utilized within safe and effective limits, minimizing any potential risks to users. Overall, Homosalate's inclusion in sunscreen formulations plays a vital role in enhancing the efficacy and user-friendliness of sun protection products, thus promoting healthier skin and reducing the risk of sun-induced damage.

Is Homosalate safe for use on sensitive skin?
When considering the safety profile of Homosalate for sensitive skin, it's important to evaluate its potential for causing irritation or allergic reactions. Generally speaking, Homosalate is considered safe for use in sunscreen products, as evidenced by its approval from regulatory bodies like the FDA and EMA. However, individuals with sensitive skin may react differently to various ingredients, including Homosalate. In contact with sensitive skin, Homosalate is often well-tolerated, but as with any topical agent, there is a possibility of causing irritation or an allergic reaction in some individuals.

For those with particularly sensitive or reactive skin, patch testing is a recommended practice before fully incorporating a new product into a skincare routine. This involves applying a small amount of the sunscreen containing Homosalate to a discreet area of the skin (such as the inner forearm) and observing for any signs of redness, itching, or discomfort over the next 24 to 48 hours. If no adverse reaction occurs, the product is likely safe for use on the face and body.

Sensitive skin can sometimes react to other components in a sunscreen formula, such as preservatives, fragrances, or additional UV filters, rather than to Homosalate itself. Hence, for individuals with sensitive skin, it is beneficial to choose products labeled as "hypoallergenic," "fragrance-free," or those specifically designed for sensitive skin. These products often minimize the risk of irritation by excluding known irritants or allergens.

Scientific studies and dermatological reviews have generally not linked Homosalate with significant adverse effects at the concentrations used in cosmetic products. It adds to the compound’s favorability in sunscreens designed for a broad range of skin types, including sensitive ones. However, individuals with a history of skin allergies or those who experience any discomfort should consult with a dermatologist to determine the most suitable sun protection regimen. Balancing effective sun protection while maintaining skin health is achievable with the right product selection, and Homosalate can be part of that strategy for many users.

What are the environmental impacts of Homosalate?
The environmental impact of Homosalate, like many chemical UV filters, is a growing concern among researchers, environmentalists, and consumers. When sunscreen is worn into the ocean, rivers, and lakes or washed off in the shower, chemical ingredients can enter aquatic environments, potentially affecting wildlife and ecosystems. Studies have indicated that certain sunscreen ingredients may have detrimental effects on marine life, particularly on coral reefs, fish, and other organisms.

As for Homosalate specifically, it is part of ongoing research to understand its ecological footprint better. Preliminary studies suggest that Homosalate can accumulate in the environment and may pose risks to aquatic life. Homosalate's persistence and potential bioaccumulation in aquatic organisms are areas of concern. While not as extensively studied as some other UV filters like oxybenzone, available data suggest that Homosalate could contribute to adverse effects on marine ecosystems, especially with high-density tourist areas where sunscreen use is prolific.

The European Union has taken steps to evaluate the environmental safety of various cosmetic ingredients, including Homosalate, to ensure they do not pose significant risks to the environment. Although Homosalate is still widely used, it is under continuous review, and results from ongoing studies will further inform regulatory guidelines and potential future restrictions or recommendations.

To mitigate potential environmental impacts, several measures can be adopted. The use of "reef-safe" or "ocean-friendly" sunscreens, which exclude harmful UV filters, is becoming increasingly popular. These formulations typically avoid ingredients like Homosalate, oxybenzone, and octinoxate, opting instead for mineral UV filters such as zinc oxide or titanium dioxide, which are considered safer for aquatic life.

Innovations in sunscreen formulations are geared towards reducing ecological footprints. Companies are increasingly investing in research to develop sunscreens that offer effective UV protection while posing minimal environmental risks. Alongside these advancements, increasing public awareness about the environmental impacts of sunscreen ingredients can help drive more sustainable choices among consumers. In conclusion, while Homosalate is an effective UV filter with a generally safe profile for humans, its potential environmental impacts warrant cautious use and further research to ensure the protection of marine ecosystems.

How does Homosalate compare to other sunscreen ingredients?
Homosalate is one of several UV filters used in sunscreens, each with its own set of strengths and limitations. Comparing Homosalate to other common sunscreen ingredients can help consumers make informed choices about their sun protection needs.

Firstly, Homosalate primarily protects against UVB radiation (290-320 nm), which is responsible for causing sunburn and contributing to skin cancer. In contrast, other chemical UV filters like Avobenzone offer protection against UVA rays (320-400 nm), which penetrate the skin more deeply and contribute to premature aging and DNA damage. To provide broad-spectrum protection, sunscreens often formulate multiple UV filters together, combining Homosalate with ingredients like Avobenzone, Octocrylene, or Oxybenzone, thereby covering a broader range of the UV spectrum.

When compared to mineral sunscreens that use physical UV filters such as zinc oxide or titanium dioxide, Homosalate offers different benefits. Mineral sunscreens create a physical barrier that reflects and scatters UV radiation. These ingredients are photostable, meaning they do not degrade when exposed to sunlight and are less likely to cause skin irritation, making them a preferred choice for sensitive skin. On the downside, mineral sunscreens can leave a white cast on the skin and may be less cosmetically appealing for daily use, particularly for individuals with darker skin tones.

In terms of formulation, Homosalate is favored for its compatibility with other sunscreen ingredients and its ability to enhance the overall SPF of a product. It is oil-soluble, making it easy to incorporate into various formulations, including lotions, creams, and sprays. Furthermore, Homosalate helps improve the spreadability and absorbency of sunscreen products, making them more pleasant to apply.

One area where Homosalate differs from some other UV filters is its regulatory status. For example, the FDA approves Homosalate at concentrations up to 15%, while the EMA permits up to 10%. In contrast, other UV filters like Oxybenzone, a highly effective UV filter, are scrutinized due to concerns about hormone disruption and environmental impact, leading to calls for reduced usage or bans in specific regions.

The environmental impact is another crucial differentiation. While Homosalate's ecological risks are still under study, other filters like Oxybenzone and Octinoxate have well-documented harmful effects on coral reefs and marine life, prompting bans in certain tourist destinations like Hawaii and Palau. These factors have accelerated a shift towards "reef-safe" sunscreen options, which typically exclude such ingredients.

Ultimately, while Homosalate provides essential UVB protection and is a valuable component in multi-filter sunscreens, its best use often lies in conjunction with other ingredients to ensure broad-spectrum protection, stability, and user satisfaction. Each sunscreen ingredient offers unique advantages, and understanding these differences helps in selecting a product that aligns with individual skin needs and environmental considerations.

Can pregnant women safely use sunscreens containing Homosalate?
The safety of using sunscreens containing Homosalate during pregnancy is a subject of interest for many expecting mothers who are understandably cautious about the products they use. Generally, sunscreen use is strongly recommended for pregnant women to protect against the harmful effects of UV radiation, which can lead to skin cancer and hyperpigmentation conditions such as melasma, more common during pregnancy due to hormonal changes.

Homosalate is approved by regulatory agencies such as the FDA and EMA for use in over-the-counter sunscreens, and it is considered safe when used within the recommended concentrations. However, like any topical agent, even those approved for general use, it is always advisable for pregnant women to exercise caution and choose products deliberately.

Current scientific data does not conclusively indicate that Homosalate poses any significant risks to maternal or fetal health when used according to guidelines. The compound is absorbed minimally through the skin and unlikely to reach concentrations that could cause harm. Nevertheless, there is ongoing research regarding the systemic absorption and potential endocrine-disrupting effects of various chemical UV filters, including Homosalate. While the evidence is not robust enough to necessitate avoidance, it warrants a cautious approach, particularly given the broad range of alternatives available.

For pregnant women concerned about any chemical exposure, mineral sunscreens containing physical blockers like zinc oxide or titanium dioxide are often recommended. These ingredients sit on the skin's surface and reflect UV rays, providing effective protection without being absorbed into the skin. Mineral sunscreens are less likely to cause skin irritation and do not have the potential endocrine-disrupting concerns associated with some chemical filters.

In practice, the safest approach for pregnant women may involve using a broad-spectrum sunscreen that combines physical blockers with chemical filters within regulated limits. Look for products labeled as "broad-spectrum," indicating they protect against both UVA and UVB rays, and those designated "sensitive skin" or "mineral-based" for a safer profile. Consulting a healthcare provider or a dermatologist can provide additional guidance tailored to individual health needs and concerns.

Overall, the use of sunscreens, including those containing Homosalate, is generally considered safe and beneficial for pregnant women when used as directed. Protecting the skin from UV damage is crucial, and with informed choices, it is possible to do so effectively while minimizing any potential risks associated with specific sunscreen ingredients.
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