| product_name | 
                    Homosalate | 
                
                
                    | CAS_number | 
                    118-56-9 | 
                
                
                    | formula | 
                    C16H22O3 | 
                
                
                    | molar_mass | 
                    262.35 g/mol | 
                
                
                    | pub_chem_CID | 
                    23966 | 
                
                
                    | drug_bank | 
                    DB11017 | 
                
                
                    | chem_spider | 
                    22410 | 
                
                
                    | bioavailability | 
                    Not well characterized | 
                
                
                    | protein_binding | 
                    High (likely to plasma proteins) | 
                
                
                    | metabolism | 
                    Primarily hepatic | 
                
                
                    | elimination_halflife | 
                    Uncertain | 
                
            
            
            
            FAQ
            
                What is Homosalate and how does it work in sunscreen formulations?
Homosalate is an organic compound
                predominantly used in sunscreen formulations. It belongs to the salicylate class of chemicals and
                functions as a UV filter. The primary role of Homosalate is to absorb ultraviolet (UV) radiation from
                the sun, specifically UVB rays, which are primarily responsible for causing sunburn and contributing to
                skin cancer. When applied to the skin in the form of a sunscreen, Homosalate absorbs these harmful rays
                and converts them into less harmful heat, which is then released from the skin. This process helps to
                protect the skin cells from damage caused by UV exposure.
In the broader spectrum of sunscreen
                ingredients, Homosalate is valued for its ability to blend well with other chemicals and enhance the
                overall UV protection of the product. Often, sunscreens combine multiple UV filters to ensure
                comprehensive protection against both UVA and UVB rays. Homosalate pairs effectively with other UV
                filters like Avobenzone or Octocrylene, providing a synergistic effect that results in higher SPF
                formulations. Another advantage of Homosalate is its compatibility with cosmetic formulations, as it
                does not impart an unpleasant odor or greasy feel, contributing to the overall consumer appeal of the
                sunscreen products.
Homosalate operates within the permissible concentrations defined by
                regulatory authorities such as the U.S. Food and Drug Administration (FDA) and the European Medicines
                Agency (EMA). Typically, it is used in concentrations up to 15% in the U.S. and 10% in Europe. These
                regulations ensure the ingredient is utilized within safe and effective limits, minimizing any potential
                risks to users. Overall, Homosalate's inclusion in sunscreen formulations plays a vital role in
                enhancing the efficacy and user-friendliness of sun protection products, thus promoting healthier skin
                and reducing the risk of sun-induced damage.
Is Homosalate safe for use on sensitive
                skin?
When considering the safety profile of Homosalate for sensitive skin, it's important to
                evaluate its potential for causing irritation or allergic reactions. Generally speaking, Homosalate is
                considered safe for use in sunscreen products, as evidenced by its approval from regulatory bodies like
                the FDA and EMA. However, individuals with sensitive skin may react differently to various ingredients,
                including Homosalate. In contact with sensitive skin, Homosalate is often well-tolerated, but as with
                any topical agent, there is a possibility of causing irritation or an allergic reaction in some
                individuals.
For those with particularly sensitive or reactive skin, patch testing is a
                recommended practice before fully incorporating a new product into a skincare routine. This involves
                applying a small amount of the sunscreen containing Homosalate to a discreet area of the skin (such as
                the inner forearm) and observing for any signs of redness, itching, or discomfort over the next 24 to 48
                hours. If no adverse reaction occurs, the product is likely safe for use on the face and
                body.
Sensitive skin can sometimes react to other components in a sunscreen formula, such as
                preservatives, fragrances, or additional UV filters, rather than to Homosalate itself. Hence, for
                individuals with sensitive skin, it is beneficial to choose products labeled as "hypoallergenic,"
                "fragrance-free," or those specifically designed for sensitive skin. These products often minimize the
                risk of irritation by excluding known irritants or allergens.
Scientific studies and
                dermatological reviews have generally not linked Homosalate with significant adverse effects at the
                concentrations used in cosmetic products. It adds to the compound’s favorability in sunscreens designed
                for a broad range of skin types, including sensitive ones. However, individuals with a history of skin
                allergies or those who experience any discomfort should consult with a dermatologist to determine the
                most suitable sun protection regimen. Balancing effective sun protection while maintaining skin health
                is achievable with the right product selection, and Homosalate can be part of that strategy for many
                users.
What are the environmental impacts of Homosalate?
The environmental impact of
                Homosalate, like many chemical UV filters, is a growing concern among researchers, environmentalists,
                and consumers. When sunscreen is worn into the ocean, rivers, and lakes or washed off in the shower,
                chemical ingredients can enter aquatic environments, potentially affecting wildlife and ecosystems.
                Studies have indicated that certain sunscreen ingredients may have detrimental effects on marine life,
                particularly on coral reefs, fish, and other organisms.
As for Homosalate specifically, it is
                part of ongoing research to understand its ecological footprint better. Preliminary studies suggest that
                Homosalate can accumulate in the environment and may pose risks to aquatic life. Homosalate's
                persistence and potential bioaccumulation in aquatic organisms are areas of concern. While not as
                extensively studied as some other UV filters like oxybenzone, available data suggest that Homosalate
                could contribute to adverse effects on marine ecosystems, especially with high-density tourist areas
                where sunscreen use is prolific.
The European Union has taken steps to evaluate the environmental
                safety of various cosmetic ingredients, including Homosalate, to ensure they do not pose significant
                risks to the environment. Although Homosalate is still widely used, it is under continuous review, and
                results from ongoing studies will further inform regulatory guidelines and potential future restrictions
                or recommendations.
To mitigate potential environmental impacts, several measures can be adopted.
                The use of "reef-safe" or "ocean-friendly" sunscreens, which exclude harmful UV filters, is becoming
                increasingly popular. These formulations typically avoid ingredients like Homosalate, oxybenzone, and
                octinoxate, opting instead for mineral UV filters such as zinc oxide or titanium dioxide, which are
                considered safer for aquatic life.
Innovations in sunscreen formulations are geared towards
                reducing ecological footprints. Companies are increasingly investing in research to develop sunscreens
                that offer effective UV protection while posing minimal environmental risks. Alongside these
                advancements, increasing public awareness about the environmental impacts of sunscreen ingredients can
                help drive more sustainable choices among consumers. In conclusion, while Homosalate is an effective UV
                filter with a generally safe profile for humans, its potential environmental impacts warrant cautious
                use and further research to ensure the protection of marine ecosystems.
How does Homosalate
                compare to other sunscreen ingredients?
Homosalate is one of several UV filters used in sunscreens,
                each with its own set of strengths and limitations. Comparing Homosalate to other common sunscreen
                ingredients can help consumers make informed choices about their sun protection needs.
Firstly,
                Homosalate primarily protects against UVB radiation (290-320 nm), which is responsible for causing
                sunburn and contributing to skin cancer. In contrast, other chemical UV filters like Avobenzone offer
                protection against UVA rays (320-400 nm), which penetrate the skin more deeply and contribute to
                premature aging and DNA damage. To provide broad-spectrum protection, sunscreens often formulate
                multiple UV filters together, combining Homosalate with ingredients like Avobenzone, Octocrylene, or
                Oxybenzone, thereby covering a broader range of the UV spectrum.
When compared to mineral
                sunscreens that use physical UV filters such as zinc oxide or titanium dioxide, Homosalate offers
                different benefits. Mineral sunscreens create a physical barrier that reflects and scatters UV
                radiation. These ingredients are photostable, meaning they do not degrade when exposed to sunlight and
                are less likely to cause skin irritation, making them a preferred choice for sensitive skin. On the
                downside, mineral sunscreens can leave a white cast on the skin and may be less cosmetically appealing
                for daily use, particularly for individuals with darker skin tones.
In terms of formulation,
                Homosalate is favored for its compatibility with other sunscreen ingredients and its ability to enhance
                the overall SPF of a product. It is oil-soluble, making it easy to incorporate into various
                formulations, including lotions, creams, and sprays. Furthermore, Homosalate helps improve the
                spreadability and absorbency of sunscreen products, making them more pleasant to apply.
One area
                where Homosalate differs from some other UV filters is its regulatory status. For example, the FDA
                approves Homosalate at concentrations up to 15%, while the EMA permits up to 10%. In contrast, other UV
                filters like Oxybenzone, a highly effective UV filter, are scrutinized due to concerns about hormone
                disruption and environmental impact, leading to calls for reduced usage or bans in specific
                regions.
The environmental impact is another crucial differentiation. While Homosalate's
                ecological risks are still under study, other filters like Oxybenzone and Octinoxate have
                well-documented harmful effects on coral reefs and marine life, prompting bans in certain tourist
                destinations like Hawaii and Palau. These factors have accelerated a shift towards "reef-safe" sunscreen
                options, which typically exclude such ingredients.
Ultimately, while Homosalate provides
                essential UVB protection and is a valuable component in multi-filter sunscreens, its best use often lies
                in conjunction with other ingredients to ensure broad-spectrum protection, stability, and user
                satisfaction. Each sunscreen ingredient offers unique advantages, and understanding these differences
                helps in selecting a product that aligns with individual skin needs and environmental
                considerations.
Can pregnant women safely use sunscreens containing Homosalate?
The safety of
                using sunscreens containing Homosalate during pregnancy is a subject of interest for many expecting
                mothers who are understandably cautious about the products they use. Generally, sunscreen use is
                strongly recommended for pregnant women to protect against the harmful effects of UV radiation, which
                can lead to skin cancer and hyperpigmentation conditions such as melasma, more common during pregnancy
                due to hormonal changes.
Homosalate is approved by regulatory agencies such as the FDA and EMA
                for use in over-the-counter sunscreens, and it is considered safe when used within the recommended
                concentrations. However, like any topical agent, even those approved for general use, it is always
                advisable for pregnant women to exercise caution and choose products deliberately.
Current
                scientific data does not conclusively indicate that Homosalate poses any significant risks to maternal
                or fetal health when used according to guidelines. The compound is absorbed minimally through the skin
                and unlikely to reach concentrations that could cause harm. Nevertheless, there is ongoing research
                regarding the systemic absorption and potential endocrine-disrupting effects of various chemical UV
                filters, including Homosalate. While the evidence is not robust enough to necessitate avoidance, it
                warrants a cautious approach, particularly given the broad range of alternatives available.
For
                pregnant women concerned about any chemical exposure, mineral sunscreens containing physical blockers
                like zinc oxide or titanium dioxide are often recommended. These ingredients sit on the skin's surface
                and reflect UV rays, providing effective protection without being absorbed into the skin. Mineral
                sunscreens are less likely to cause skin irritation and do not have the potential endocrine-disrupting
                concerns associated with some chemical filters.
In practice, the safest approach for pregnant
                women may involve using a broad-spectrum sunscreen that combines physical blockers with chemical filters
                within regulated limits. Look for products labeled as "broad-spectrum," indicating they protect against
                both UVA and UVB rays, and those designated "sensitive skin" or "mineral-based" for a safer profile.
                Consulting a healthcare provider or a dermatologist can provide additional guidance tailored to
                individual health needs and concerns.
Overall, the use of sunscreens, including those containing
                Homosalate, is generally considered safe and beneficial for pregnant women when used as directed.
                Protecting the skin from UV damage is crucial, and with informed choices, it is possible to do so
                effectively while minimizing any potential risks associated with specific sunscreen ingredients.