product_name |
1,3-Dihydroxyacetone |
CAS_number |
96-26-4 |
formula |
C3H6O3 |
molar_mass |
90.08 g/mol |
pub_chem_CID |
970 |
drug_bank |
DB02360 |
chem_spider |
945 |
bioavailability |
Not Applicable |
protein_binding |
Low |
metabolism |
Primarily hepatic |
elimination_halflife |
Short (hours) |
FAQ
What is 1,3-Dihydroxyacetone and how does it work?
1,3-Dihydroxyacetone (DHA) is a simple
carbohydrate molecule that is predominantly used in the cosmetic industry, particularly in sunless
tanning products. Structurally, it is a three-carbon sugar, which means it is chemically classified as a
triose. This compound undergoes a non-enzymatic glycation reaction with the amino acids that make up the
proteins in the stratum corneum, the outermost layer of the skin. When DHA is applied to the skin, it
interacts with amino acids like glycine, lysine, and histidine. This reaction results in the formation
of complex polymers called melanoidins, which are responsible for the brownish coloration that mimics a
sun-induced tan.
The process generally takes between 2 to 4 hours to start developing, and the
color can continue to deepen for up to 72 hours after application. The tan usually lasts between 5 to 7
days, depending on how quickly one's skin naturally exfoliates. DHA is considered safe for external use
and has been approved by various health agencies, including the US Food and Drug Administration (FDA).
This safety approval makes it a popular choice for those looking to achieve a sun-kissed glow without
the harmful effects of ultraviolet (UV) radiation.
Is 1,3-Dihydroxyacetone safe to use on all
skin types?
Yes, 1,3-Dihydroxyacetone is generally considered safe for use on all skin types.
Extensive research and regulatory reviews indicate that DHA is a safe and effective ingredient for
cosmetic applications, including sunless tanning products. The compound works by reacting only with the
outermost layer of the skin, the stratum corneum, and does not penetrate into deeper layers. Therefore,
its interaction with living cells is minimal. This limited interaction makes it suitable for use on
various skin types including sensitive skin. However, it is always advisable to perform a patch test
before using any new product to ensure there are no adverse reactions.
People with particularly
sensitive skin may experience mild irritation or an allergic reaction. These reactions are generally
rare but can include redness, itching, or a slight burning sensation. If any adverse symptoms occur, it
is recommended to discontinue use immediately and consult a healthcare provider. For individuals with
pre-existing skin conditions such as eczema or psoriasis, consulting a dermatologist before using
DHA-based products is recommended. Additionally, it is crucial to follow the instructions on the product
label for correct usage to mitigate any risks.
How long does the tan from 1,3-Dihydroxyacetone
last?
The tan obtained from 1,3-Dihydroxyacetone typically lasts between 5 to 7 days. The
longevity of the tan is directly related to the natural skin exfoliation process. As the outer layer of
the skin sheds, the melanoidin complex formed by the reaction of DHA with skin proteins also sheds.
Therefore, activities that accelerate skin exfoliation, such as frequent bathing, swimming, or
scrubbing, can shorten the lifespan of the tan. Conversely, moisturizing can help prolong the tan by
slowing down the exfoliation process.
To maintain the tan for as long as possible, a few
precautions can be taken. It is advisable to avoid prolonged water exposure for the first 4 to 6 hours
after application, as water can interfere with the development process. Also, using moisturizers and
hydrating lotions can keep the skin in optimal condition, thereby extending the duration of the tan. It
is also worth noting that excessive sweating and physical activities that cause friction can also affect
the longevity of the tan.
Regular touch-ups can keep the tan looking fresh, and some products may
contain additional ingredients like erythrulose that work synergistically with DHA to provide a
longer-lasting tan. However, the core duration remains influenced by individual skin types and care
routines.
Can 1,3-Dihydroxyacetone be used in formulations other than tanning
products?
Yes, 1,3-Dihydroxyacetone has applications beyond tanning products, although sunless
tanners remain its most popular use. In recent years, DHA has been explored for its potential in various
dermatological and cosmetic formulations. For instance, it is sometimes added to anti-aging products to
provide a subtle, temporary tint that helps even out skin tone and impart a healthy glow. Some
researchers have also explored its use in treating skin conditions like vitiligo, as it provides a
temporary pigmentation that helps camouflage depigmented patches.
Moreover, DHA is being
investigated for its role as a humectant and moisturizing agent, given its ability to bind water
molecules and improve skin hydration. This property makes it a candidate for inclusion in lotions,
creams, and other skincare formulations aimed at maintaining skin moisture. Furthermore, DHA's
reactivity with proteins has led to its experimental use in hair care products, where it may help
improve the appearance of hair by reacting with the keratin.
It’s important to note that while
these alternative uses are promising, they are still subject to ongoing research and regulatory
approval. The effectiveness and safety of DHA in these new applications would need thorough validation
through clinical trials and scientific studies before becoming widely accepted.
How should I
prepare my skin before using a product containing 1,3-Dihydroxyacetone?
Preparing your skin
properly before applying a product containing 1,3-Dihydroxyacetone is essential for achieving an even,
streak-free tan. Start by exfoliating your skin at least 24 hours prior to application. Exfoliation
removes dead skin cells and creates a smooth surface, which helps DHA react uniformly with the proteins
in the skin. Focus on areas where the skin tends to be thicker or drier, such as elbows, knees, and
ankles to prevent these areas from absorbing more DHA and turning darker than the rest of the
body.
After exfoliating, make sure to moisturize any particularly dry areas. However, do not
apply moisturizer all over your body just before using the DHA product, as this can create a barrier and
limit the reaction between DHA and your skin. It’s best to do this the night before or wait for a few
hours to ensure proper absorption. Also, shave any necessary areas 24 hours ahead of time to avoid
irritation and ensure an even tan.
Another critical step is to apply the DHA product in sections,
such as arms, legs, and torso, to ensure even coverage. Use a tanning mitt if available; this helps
spread the product more uniformly and prevents your palms from turning orange. After application, allow
the product to dry completely before dressing. Loose clothing is recommended to prevent rubbing off the
product while it is still developing. Avoid any water contact, sweating, or applying other skincare
products for the first 4 to 6 hours to let the tan develop fully.